Differential Biochemical and Cellular Actions of Premarin Estrogens: Distinct Pharmacology of Bazedoxifene-Conjugated Estrogens Combination
نویسندگان
چکیده
منابع مشابه
Conjugated Estrogens/Bazedoxifene (Duavee) for Menopausal Symptoms.
A collection of STEPS published in AFP is available at http://www.aafp.org/ afp/steps. Conjugated estrogens/bazedoxifene (Duavee) combines conjugated estrogen with bazedoxifene, a selective estrogen receptor modulator. Bazedoxifene stimulates estrogen receptors in bone and has antagonistic effects in the breast and uterus.1 Conjugated estrogens/bazedoxifene is labeled for the treatment of moder...
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Replacement therapy with estrogens and gestagens serves the purpose of avoiding the unfavorable consequences of the loss of endogenous estradiol and progesterone production. It is not of primary importance to restore the physiological conditions of an ovula tory cycle, but much rather to realize the intended purpose of the treatment in an optimal way. Various prepara tions are available for t...
متن کاملSleep parameters and health-related quality of life with bazedoxifene/conjugated estrogens: a randomized trial.
OBJECTIVE The effects of bazedoxifene (BZA)/conjugated estrogens (CE) on sleep and health-related quality of life (HRQoL) were evaluated in nonhysterectomized postmenopausal women who were enrolled in a randomized, double-blind, placebo- and active-controlled phase 3 trial. METHODS The sleep/HRQoL substudy enrolled 459 women with bothersome moderate to severe vasomotor symptoms who were rando...
متن کاملThe Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause
The tissue-selective estrogen complex (TSEC) pairs conjugated estrogens (CE) with a selective estrogen receptor modulator (SERM), bazedoxifene acetate (BZA). A 2-year treatment with the TSEC improved vasomotor symptoms, quality of life, and vaginal atrophy in healthy postmenopausal women. In addition, the TSEC prevented vertebral and hip bone loss without increasing mammographic density, breast...
متن کاملPatient considerations in the management of menopausal symptoms: role of conjugated estrogens with bazedoxifene
Menopausal symptoms (eg, hot flushes and vaginal symptoms) are common, often bothersome, and can adversely impact women's sexual functioning, relationships, and quality of life. Estrogen-progestin therapy was previously considered the standard care for hormone therapy (HT) for managing these symptoms in nonhysterectomized women, but has a number of safety and tolerability concerns (eg, breast c...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2009
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2008-0366